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  • Selective Colorimetric Detection ofScience

    A highly selective, colorimetric polynucleotide detection method based on mercaptoalkyloligonucleotide-modified gold nanoparticle probes is reported. Introduction of a single-stranded target oligonucleotide (30 bases) into a solution containing the appropriate probes resulted in the formation of a polymeric network of nanoparticles with a concomitant red-to-pinkish/purple color change.

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  • Gold Nanoparticle Mediated Phototherapy for Cancer.

    As to the currently available gold nanoparticle-based therapeutic approaches, they can be classified into four main types (1) photothermal therapy upon irradiation of surface plasmon resonant gold nanoparticles by light, surface electrons are excited and resonate intensely, and fast conversion of light into heat takes place in about 1ps [20].

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  • Preparation of [C60]Fullerene Nanowhisker-gold

    A gold nanoparticle solution was prepared by adding sodium borohydride (NaBH 4), trisodium citrate dihydrate (C 6 H 5 Na 3 O 7 ·2H 2 O), cetyltrimethyl ammonium bromide (CTAB,(C 16 H 33)N(CH 3) 3 Br), ascorbic acid (C 6 H 8 O 6), and potassium tetrachloroaurate(III)(KAuCl 4) to distilled water and stirring the solution for 15 min. [C 60]fullerene nanowhisker-gold nanoparticle composites were

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  • Robust and accurate measurements of gold nanoparticle

    A detailed investigation of the uncertainties of DCS, with a detector operating at a wavelength of 405 nm and a fluid with a refractive index greater than that of water led to a deeper insight into the use of UV-visible spectrophotometry for gold nanoparticle concentration.

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  • High-Resolution Nanoparticle Sizing with Maximum A

    The rapid and efficient characterization of polydisperse nanoparticle dispersions remains a challenge within nanotechnology and biopharmaceuticals. Current methods for particle sizing, such as dynamic light scattering, analytical ultracentrifugation, and field-flow fractionation, can suffer from a combination of statistical biases, difficult sample preparation, insufficient sampling, and ill

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  • Research Gold Nanoparticle Cancer Research

    In nanoparticle form, gold is being implemented for cancer treatment, and bacteria/enzyme identification. Gold nano-powder provides a promising role in targeting prostate cancer cells. Gold has a quality that makes it ideal in cancer cell detection; this property is the ability to scatter and absorb light.

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  • Biological mechanisms of gold nanoparticle

    Gold nanoparticle-mediated enhanced radiosensitization has been achieved by several research groups. It was found using 50-nm GNPs that radiosensitized HeLa cells when irradiated with 220 kVp X-rays giving a DEF (dose enhancement factor) of 1.43 greater than that observed for smaller nanoparticles (from 14 to 74 nm).

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  • Characteristics of Secondary Electrons from Irradiated

    The effective range, maximum deflection angle, interaction parameters, and energy deposition of secondary electrons emitted from a gold nanoparticle irradiated by photon beams were calculated by means of Monte Carlo simulations.

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  • Biological mechanisms of gold nanoparticle radiosensitization

    Gold nanoparticle-mediated enhanced radiosensitization has been achieved by several research groups. It was found using 50-nm GNPs that radiosensitized HeLa cells when irradiated with 220 kVp X-rays giving a DEF (dose enhancement factor) of 1.43 greater than that observed for smaller nanoparticles (from 14 to 74 nm).

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  • Chapter 7 Interaction of Gold Nanoparticle with Proteins

    Chapter 7 Interaction of Gold Nanoparticle with Proteins 157 UV-visible spectrophotometer. The instrument was operated in spectrum mode with a wavelength interval 1 nm and sample holder was quartz cell of path length 1 cm. SANS has been used to examine the structures of gold nanoparticle-protein conjugates upon their interaction.

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  • () Probing the colloidal gold nanoparticle/aqueous

    The interface of 16 nm colloidal gold nanoparticles with the aqueous solution in which they are sus- pended is investigated using second harmonic generation. The population of malachite green freely adsorbing to the gold nanoparticle interface as a

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  • Pinhole X-ray fluorescence imaging of gadolinium and

    Pinhole X-ray fluorescence imaging of gadolinium and gold nanoparticles using polychromatic X-rays a Monte Carlo study Seongmoon Jung,1,2 Wonmo Sung,1,2 Sung-Joon Ye13 1Department of Transdisciplinary Studies, Graduate School of Convergence Science and Technology, Seoul National University, Seoul, Republic of Korea; 2Biomedical Research Institute, College of Medicine, Seoul

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    Gap-Plasmon Enhanced Gold Nanoparticle Photoluminescence

    ABSTRACT Gap-plasmon-enhanced gold nanoparticle photoluminescence is studied experimentally at the single-particle level. The photoluminescence spectra of gold nanoparticles on an Al 2 O 3-coated gold film under both 532 and 633 nm excitation show a clear peak near the measured gap-plasmon resonance wavelength.

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  • COLORIMETRIC SCREENING OF OLIGONUCLEOTIDE BASED ON

    Colorimetric screening, gold nanoparticle, oligonucleotide, hybridization INTRODUCTION Gold nanoparticles (AuNPs) are increasingly applied in biochemistry and engineering because of their size-dependent optical properties, great surface modifiability and

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  • Nanoparticle Optical Properties Size Dependence of a

    The optical properties of a spherical gold nanoparticle have become our interest due to its remarkable characteristics when interacting with the light. In this work, the dependence of surface plasmon resonance on the size of the gold nanosphere has been studied with varying diameter from 20 to 100 nm. The optical spectra of the single isolated gold nanoparticles are simulated by employing the

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  • Plastic-Compatible Low Resistance Printable Gold

    discuss the optimization of the process to demonstrate plastic-compatible gold conductors for the first time. By optimizing both the size of the nanoparticle and the length of the alkanethiol encapsulant, it is possible to produce particles that anneal at low temperatures (,150°C) to form continuous gold films having low resistivity.

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  • Catalytically Active PeptideGold Nanoparticle Conjugates

    1 Introduction. Enzymes play a crucial role in accelerating virtually every organic transformation in nature, with unrivalled catalytic efficiency and specificity under mild conditions. 1, 2 The superior catalytic performance of enzymes is directly related to their complex, folded protein structure, which accounts for the highly sophisticated enzymesubstrate interactions, 3 but also for the

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    Nanosensors Based on Responsive Polymer Brushes and

    P2VP, and gold nanoparticle layers were monitored by T-SPR (Figure 2), AFM scratch test, and SPR (see Supporting Information). The gold nanoparticles formed a fairly closed-packed uniform coverage on the polymer brushes, as evidenced by AFM (see Supporting Information). The absorption maximum of the T-SPR spectrum of the gold

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  • Scanometric DNA Array Detection with Nanoparticle Probes

    A method for analyzing combinatorial DNA arrays using oligonucleotide-modified gold nanoparticle probes and a conventional flatbed scanner is described here. Labeling oligonucleotide targets with nanoparticle rather than fluorophore probes substantially alters the melting profiles of the targets from an array substrate. This difference permits the discrimination of an oligonucleotide sequence

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  • Silver Nanoparticle Properties Bio-Synthesis, Inc.

    Silver nanoparticle size dependant surface plasmon resonance. Note the red-shift of the absorption maximum as the gold nanoparticle size increases. The aggregation state of silver nanoparticles also has significant effect on their optical properties. This fact can be used to monitor the stability of silver nanoparticles, both over time, and

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  • FrontiersRapid Colorimetric Assay for Detection of

    Listeria monocytogenes is a major foodborne pathogen of global health concern. Herein, the rapid diagnosis of L. monocytogenes has been achieved using loop-mediated isothermal amplification (LAMP) based on the phosphatidylcholine-phospholipase C gene (plcB). Colorimetric detection was then performed through the formation of DNA concatemers and a gold nanoparticle/DNA probe complex

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    Determination of thiamine in solution by UV-visible

    solution of thiamine with a gold nanoparticle solution. The gold nanoparticles were synthesized via a citrate reduction method used in previous studies. 6 The changes in the absorbance spectrum were measured and the selectivity was estimated by performing the same method of determination on amino acid solutions. A limit of detection was also

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  • In vivo and In vitro Toxicity and Anti-Inflammatory

    Gold nanoparticle (AuNP) bioconjugates have been used as therapeutic and diagnostic tools; however, in vivo biocompatibility and cytotoxicity continue to be two fundamental issues. The effect of AuNPs (20 nm) conjugated with antibody [immunoglobulin G (IgG)], albumin, protein A, PEG4000, and citrate ( cit ) were evaluated in vitro using primary

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  • Novel Polyamide Nanocomposite with Montmorillonite Clay

    Novel Polyamide Nanocomposite with Montmorillonite Clay and Gold Nanoparticle Nanofillers . Ayesha Kausar. Nanosciences Division, National Centre For Physics, Quaid-i-Azam University Campus, Islamabad, Pakistan . Abstract In this attempt, a novel polyamide was prepared using 2-aminoethanethiol hydrochloride and

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  • Maximizing DNA loading on a range of gold nanoparticle

    Maximizing DNA loading on a range of gold nanoparticle sizes.Abstract. We have investigated the variables that influence DNA coverage on gold nanoparticles. The effects of salt concentration, spacer composition, nanoparticle size, and degree of sonication have been evaluated. Maximum loading was obtained by salt aging the nanoparticles to

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  • Gold Nanoparticle Archilys

    Gold Nanoparticle. Gold nanoparticles, an old and new material. Localized plasmon, an optical technology in the 21st century. Noble metals like gold and silver delight our life with the charming shining. While metallic gold has "golden-color" gleam, gold in the state of particles smaller than the wavelength of visible light also shows the

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  • Scanometric DNA Array Detection with Nanoparticle

    A method for analyzing combinatorial DNA arrays using oligonucleotide-modified gold nanoparticle probes and a conventional flatbed scanner is described here. Labeling oligonucleotide targets with nanoparticle rather than fluorophore probes substantially alters the melting profiles of the targets from an array substrate. This difference permits the discrimination of an oligonucleotide sequence

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  • A local effect model-based interpolation framework for

    A local effect model (LEM)-based framework capable of interpolating nanoparticle-enhanced photon-irradiated clonogenic cell survival fraction measurements as a function of nanoparticle concentration was developed and experimentally benchmarked for gold nanoparticle (AuNP)-doped bovine aortic endothelial cells (BAECs) under superficial kilovoltage X-ray irradiation.

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  • Designing Aptamer-Gold Nanoparticle-Loaded pH

    3/30/2021 · This study proposes the synthesis of a type of anticancer nanoparticle, aptamers and Au nanoparticle (Apt-Au)-modified Morin pH-sensitive liposome (MSL), which exhibits targeting properties. Tumors are difficult to cure because their microenvironment varies from that of normal tissue; its pH is lower than that of normal tissue, which generally impedes the effectiveness of drugs.

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  • US8241393B2 Methods and articles for gold nanoparticle

    An example embodiment of a method for making gold nanoparticles includes steps of reacting a gold salt with a phosphino amino acid. Example phosphino amino acids include trimers, with a particular example being a trimeric amino acid conjugate containing one phosphino group. In an example method of the invention, the gold nanoparticles may be produced in timer periods of less than about 3

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  • Nanoparticlebiomolecule conjugate Wikipedia

    A nanoparticlebiomolecule conjugate is a nanoparticle with biomolecules attached to its surface. Nanoparticles are minuscule particles, typically measured in nanometers (nm), that are used in nanobiotechnology to explore the functions of biomolecules. Properties of the ultrafine particles are characterized by the components on their surfaces more so than larger structures, such as cells

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  • Site Selective Nucleation and Size Control of Gold

    Steven O.; et al. (2021) Site Selective Nucleation and Size Control of Gold Nanoparticle Photothermal Antennae on the Pore Structures of a Virus and Confined Drug Delivery. ChemRxiv. Preprint. In this article, we show that the surface of the bacteriophage Qβ is equipped with natural ligands for the synthesis of small gold nanoparticles.

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